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GATA-3 localization shapes lymphocyte function
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DOI：10.1016/j.celrep.2026.116925.png)
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Abstract
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• GATA-3 accumulates in the nucleus of progenitor and type 2 but not type 1 Th cells and ILCs • Reprogramming of Th1 and Th2 cells reverses GATA-3 localization, thus altering gene expression • Importin-β mediates the import of GATA-3 into the nucleus • Short half-life of nuclear GATA-3 requires its continuous import to maintain Th2 cell function
Keywords:
transcription factor
GATA-3
importin-β
importazole
nuclear import
intracellular compartmentalization
T helper cell
innate lymphoid cell
LCMV
Th1 and Th2 cell reprogramming
CP: immunology
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