1
Return

Gemcitabine enhanced the sensitivity of colorectal cancer to anti-PD-L1 therapy by promoting lactylation

delete2026-06-20
delete0
PRE
AI
J
Jing Gong
C
Chengjiang Fan
J
Jianing Chen
S
Shuhui Xu
H
Haizhong Jiang
D
Desen Sun
Q
Qiang Chen
Q
Qi Liao *
Y
Yang Xi *
DOI：10.1016/j.intimp.2026.117057delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• Gemcitabine promoted PD-L1 expression through lactate metabolism. • Lactytion of H3 and PD-L1 increased PD-L1 level. • Gemcitabine combined with PD-L1 antibody had synergistic therapeutic effects on colorectal cancer.

Journal

International Immunopharmacology cover
International Immunopharmacology
IF:
4.7
Papers:
1.6W
Citations:
4.1W

Organization

N
ningbo university
Scholars:
4.5K
Papers: 1.4K
Citations: 0
T
The First Affiliated Hospital of Ningbo University
Scholars:
98
Papers: 28
Citations: 0
Cited Papers

Cited Papers

Citing Papers

Citing Papers