1
Return

Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

delete2026-06-08
delete0
delete
OA
AI
Z
Zehra Abay-Nørgaard
A
Anika K. Mueller
E
Erno Hänninen
D
Dylan Rausch
L
Louise Piilgaard
L
Lucía Sena Trujillo
L
Lorenzo Fedrizzi
J
Jens Bager Christensen
A
Alison Salvador
A
Alrik L. Schörling
N
Noah Wulff Mottelson
Q
Qiuyu Qin
S
Shruthi Sampath
B
Bob Hersbach
J
Jonas Henkenjohann
S
Sofie Peeters
V
Viktoriia Nikulina
C
Charlotte Høy Kruse
Y
Yuan Li
K
Kavitha Chinnaiya
DOI：10.1016/j.stem.2026.05.005delete
deleteOriginal
deleteShare
deleteSave
View PDF
Abstract

Abstract

En 中文
• ARC-specific cell types from NKX2.1+/RAX+/FGF10+/TBX3+ posterior tuberal progenitors • ARC neurons and tanycytes functionally respond to leptin, ghrelin, LEAP2, FGF1, and GLP-1 • ARC versus VMH fate is controlled by a temporal wave of BMP • POMC neurons exist in two subtypes—one of which is not associated to the ARC
Keywords:
hypothalamic development
arcuate nucleus
human pluripotent stem cells
organoids
BMP signaling
obesity
neuropeptidergic
orexigenic
energy homeostasis
POMC development
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Stem Cell cover
Cell Stem Cell
IF:
20.4
Papers:
3.6K
Citations:
3.1W

Organization

No organization information available
Cited Papers

Cited Papers

Citing Papers

Citing Papers