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Generation of spermatogonia from human and non-human primate pluripotent stem cells
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DOI：10.1016/j.stem.2026.06.001.png)
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Abstract
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• Human and macaque iPSCs generate spermatogonia after testis reconstitution • Induced germ cells form xenogeneic reconstituted testes with mouse somatic cells • Differentiated germ cells recapitulate in vivo phenotypes and transcriptomes • iPSC-derived spermatogonia express prepachytene piRNAs
Keywords:
in vitro gametogenesis
spermatogonia
spermatogenesis
prospermatogonia
piRNA
reconstituted testis
human male germ cells
induced pluripotent stem cells
primordial germ cells
xenogeneic reconstituted testis
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