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Genetic Code Expansion: Inception, Development, Commercialization
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DOI：10.1021/jacs.0c11938.png)
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Abstract
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Virtually all natural proteins are built from only 20 amino acids, and while this makes possible all the functions they perform, the ability to encode other amino acids selected for specific purposes promises to enable the discovery and production of proteins with novel functions, including therapeutic proteins with more optimal drug-like properties. The field of genetic code expansion (GCE) has for years enabled the production of such proteins for academic purposes and is now transitioning to commercialization for the production of more optimal protein therapeutics. Focusing on E. coli, we review the history and current state of the field. We also provide a review of the first generation commercialization efforts, the lessons learned, and how those lessons are guiding new efforts. With continued academic and industrial progress, GCE methodologies promise to make possible the routine optimization of proteins for therapeutic use in a way that has only previously been possible with small-molecule therapeutics.
Keywords:
TRANSFER-RNA SYNTHETASE
COLONY-STIMULATING FACTOR
UNNATURAL AMINO-ACIDS
IN-VIVO INCORPORATION
OCCURRING CLINICAL MASTITIS
SUPPRESSOR TRANSFER-RNAS
GROWTH-FACTOR 21
LEPTIN PEG-OB
SEMISYNTHETIC ORGANISM
ESCHERICHIA-COLI
Journal
IF:
15.6
Papers:
20.0W
Citations:
60.2W
Organization
No organization information available
Cited Papers
Multiplexed genomic encoding of non-canonical amino acids for labeling large complexes.png)
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