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Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression
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DOI：10.1016/j.tig.2018.05.006.png)
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Abstract
En 中文
The phenotypic consequences of a given mutation can vary across individuals. This so-called background effect is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis often remains unclear. Taking insights gained from recent large-scale surveys of genetic interaction and suppression analyses in yeast, we propose that the genetic network context for a given mutation may shape its propensity of exhibiting background-dependent phenotypes. We argue that further efforts in systematically mapping the genetic interaction networks beyond yeast will provide not only key insights into the functional properties of genes, but also a better understanding of the background effects and the (un) predictability of traits in a broader context.
Keywords:
SICKLE-CELL-DISEASE
MENDELIAN DISORDERS
NATURAL VARIATION
CYSTIC-FIBROSIS
MODIFIER GENES
GENOME
YEAST
DROSOPHILA
TRAITS
ESSENTIALITY
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