Genetic variants of thioredoxin interacting protein gene and their association with diabetic peripheral neuropathy in type 2 diabetes mellitus

Qianqian Zhang

doi:10.1016/j.gene.2026.150271

Genetic variants of thioredoxin interacting protein gene and their association with diabetic peripheral neuropathy in type 2 diabetes mellitus

2026-06-14

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AI

Q

Qianqian Zhang

H

Hongmin Li

Y

Yongcai Zhao *

X

Xiaonan Liu

Q

Qianqian Sun

J

Jing Li

DOI：10.1016/j.gene.2026.150271

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Abstract

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• Identified TXNIP rs7211 and rs7212 as novel genetic risk loci for diabetic peripheral neuropathy in Chinese T2DM patients. • Demonstrated that AA genotype at rs7211 and CC genotype at rs7212 independently increase DPN risk. • Applied Holm-Bonferroni correction to enhance statistical power, outperforming traditional Bonferroni in SNP association analysis. • Provided first evidence linking TXNIP 3′UTR polymorphisms to DPN susceptibility, supporting oxidative stress-inflammation pathway involvement.

Genetic variants of thioredoxin interacting protein gene and their association with diabetic peripheral neuropathy in type 2 diabetes mellitus

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