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Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease

delete2026-07-09
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OA
AI
Y
Yisu Yang
A
Anna Lorenz
A
Aditi Sathe
K
Kurt G. Schilling
L
Leslie S. Gaynor
S
Seo-Eun Choi
M
Michael L. Lee
P
Phoebe Scollard
E
Emily H. Trittschuh
S
Shubhabrata Mukherjee
J
Jesse Mez
L
Logan C. Dumitrescu
B
Bennett A. Landman
P
Paul K. Crane
M
Michael L. Cuccaro
T
Timothy J. Hohman
D
Derek B. Archer *
DOI:10.1002/alz.71663delete
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Abstract

Abstract

En 中文
Memory is a strong endophenotype for Alzheimer's disease (AD) but is typically detectable only after substantial brain change. Genetically linking late-life memory with mid-life brain traits may identify early markers of AD-related cognitive decline.
Keywords:
aging
Alzheimer's disease
genetic covariance
memory
multimodal magnetic resonance imaging (MRI)
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alzheimer's & dementia
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