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Genome editing
DOI:10.1038/s41598-022-24850-x.png)
Abstract
En 中文
Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems. This Collection highlights results in CRISPR/Cas technology that increase the efficiency of precision genome editing, and allow genetic manipulation in model systems traditionally intractable to site-directed gene modification.
Keywords:
ONE-STEP GENERATION
DNA
CRISPR/CAS
GENES
CELLS
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.9
Papers:
28.0W
Citations:
83.5W
Organization
Cited Papers
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
NATURE COMMUNICATIONS
IF15.7
Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
NATURE COMMUNICATIONS
IF15.7
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
NATURE COMMUNICATIONS
IF15.7
Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization
SCIENTIFIC REPORTS
IF3.9

