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Genome editing

delete2022-11-28
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OA
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M
Maura McGrail *
T
Tetsushi Sakuma
L
Leonidas Bleris
DOI:10.1038/s41598-022-24850-xdelete
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Abstract

Abstract

En 中文
Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems. This Collection highlights results in CRISPR/Cas technology that increase the efficiency of precision genome editing, and allow genetic manipulation in model systems traditionally intractable to site-directed gene modification.
Keywords:
ONE-STEP GENERATION
DNA
CRISPR/CAS
GENES
CELLS
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Scientific Reports cover
Scientific Reports
IF:
3.9
Papers:
28.0W
Citations:
83.5W

Organization

I
Iowa State University
Scholars:
2.1W
Papers: 1.8W
Citations: 2.5W
U
university of texas system
Scholars:
18.5W
Papers: 15.6W
Citations: 210
H
Hiroshima University
Scholars:
2.1W
Papers: 1.5W
Citations: 1.3W
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Cited Papers

Cited Papers

Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
err2017-05-12
err203
errOAAI
errKwon, Deborah Y.; Zhao, Ying-Tao; Lamonica, Janine M.; Zhou, Zhaolan
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Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
err2014-11-20
err438
errOAAI
errNakade, Shota; Tsubota, Takuya; Sakane, Yuto; Kume, Satoshi; Sakamoto, Naoaki; Obara, Masanobu; Daimon, Takaaki; Sezutsu, Hideki; Yamamoto, Takashi; Sakuma, Tetsushi; Suzuki, Ken-ichi T.
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Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
err2016-08-10
err215
errOAAI
errCano-Rodriguez, David; Gjaltema, Rutger A. F.; Jilderda, Laura J.; Jellema, Pytrick; Dokter-Fokkens, Jelleke; Ruiters, Marcel H. J.; Rots, Marianne G.
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Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization
err2022-02-14
err27
errOAAI
errFierro, Javier, Jr.; DiPasquale, Jake; Perez, Joshua; Chin, Brandon; Chokpapone, Yathip; Tran, An M.; Holden, Arabella; Factoriza, Chris; Sivagnanakumar, Nikhi; Aguilar, Rocio; Mazal, Sarah; Lopez, Melissa; Dou, Huanyu
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Influence of harmonic radar tag attachment on nymphal Halyomorpha halys mobility, survivorship, and detectability
err2019-12-06
err0
PREAI
errDanielle M. Kirkpatrick; Kevin B. Rice; Aya Ibrahim; William R. Morrison; Tracy C. Leskey
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