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Genomic and chromosomal Instability: Hidden drivers of Glioblastoma aggressiveness
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DOI：10.1016/j.gene.2026.150311.png)
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Abstract
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• Glioblastoma: aggressive brain tumor with poor outcomes. • Genomic and chromosomal instability drive tumor evolution. • Instability fuels heterogeneity and therapy resistance. • Targeting genomic and chromosomal instability offers new therapeutic opportunities.