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Genomic characterization of multidrug-resistant Enterobacter asburiae clinical isolates co-harboring mcr-9 and blaIMP-8
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DOI：10.1016/j.jgar.2026.05.009.png)
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Abstract
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• ECC isolates co-harboring blaIMP-8 and mcr-9 from sterile sites underwent WGS. • MDR gene clusters are conserved across epidemiologically distinct ECC isolates. • MDR cassette showed >99.9% identity to pEC-IMPQ over 42 kb with only 4 SNPs. • All isolates were colistin-susceptible despite mcr-9 carriage, suggesting latency. • Genotype-phenotype discordance may lead to underestimation of mcr-9 prevalence.
Keywords:
Enterobacter cloacae complex
Carbapenem resistance
Metallo‑β‑lactamases
Colistin resistance
mcr-9
Whole-genome sequencing
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