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Global genomic characteristics of mobile colistin resistance mcr genes in Enterobacterales from companion animals
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DOI：10.1007/s10096-025-05368-2.png)
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Abstract
En 中文
Mobile colistin resistance (mcr) genes, initially described in livestock and humans, remain less frequently reported in companion animals. We conducted a global genomic survey of 14,643 bacterial genomes retrieved from the NCBI National Database of Antibiotic Resistant Organisms and identified 105 (0.7%) mcr-positive Enterobacterales from dogs (79.0%) and cats (21.0%). Escherichia coli (73.3%) and the Enterobacter cloacae complex (20.9%) predominated, with the mcr-1 and mcr-9 variants being the most frequent. Most genomes originated from Asia, Europe, and North America, reflecting the uneven geographic distribution of sequenced mcr-positive strains. Genomic analysis revealed a genetic plurality and co-occurrence of mcr genes with CTX-M-type extended-spectrum β-lactamases (46.6%), carbapenemases (5.7%), and 16S rRNA methyltransferases (8.6%), particularly in international high-risk clones. These findings underscore the diversity and epidemiological relevance of mcr-positive bacteria in pets, reinforcing the need for closer monitoring through One Health-based surveillance.
Keywords:
Colistin
mcr
MDR bacteria
One Health
Pets
Polymyxins
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E
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