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Global, regional, and national high LDL-cholesterol-related disease burden: an updated analysis of the Global Burden of Disease Study 2021
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DOI：10.1016/j.numecd.2026.104861.png)
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Abstract
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• Using GBD2021 data, we assessed the disease burden attributed to high LDL-C levels • Globally, overall mortality and DALY rates trended downward from 1990 to 2021 • Despite these improvements, the absolute numbers have steadily increased • Disease burden and time trends differed across regions, sexes, and age groups • Ischaemic stroke contributed more to the overall burden in older age groups • Middle-SDI regions had a higher disease burden than did other SDI regions
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