.png){kind=icon}
.png){kind=icon}
Return
Glomerular hyperfiltration
.png){kind=icon}
PRE
AI
DOI：10.1038/s41581-022-00559-y.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the glomerular filtration rate (GFR), and the total GFR is the sum of all single-nephron GFRs. Thus, when the single-nephron GFR is increased in the context of a normal number of functioning nephrons, single glomerular hyperfiltration results in 'absolute' hyperfiltration in the kidney. 'Absolute' hyperfiltration can occur in healthy people after high protein intake, during pregnancy and in patients with diabetes, obesity or autosomal-dominant polycystic kidney disease. When the number of functioning nephrons is reduced, single-nephron glomerular hyperfiltration can result in a GFR that is within or below the normal range. This 'relative' hyperfiltration can occur in patients with a congenitally reduced nephron number or with an acquired reduction in nephron mass consequent to surgery or kidney disease. Improved understanding of the mechanisms that underlie 'absolute' and 'relative' glomerular hyperfiltration in different clinical settings, and of whether and how the single-nephron haemodynamic and related biomechanical forces that underlie glomerular hyperfiltration promote glomerular injury, will pave the way toward the development of novel therapeutic interventions that attenuate glomerular hyperfiltration and potentially prevent or limit consequent progressive kidney injury and loss of function.
Keywords:
POLYCYSTIC KIDNEY-DISEASE
RENAL FUNCTIONAL RESERVE
ANGIOTENSIN-ALDOSTERONE SYSTEM
CONVERTING ENZYME-INHIBITION
DEPENDENT DIABETIC-PATIENTS
DIETARY-PROTEIN INTAKE
BODY-WEIGHT MISMATCH
AMINO-ACID INFUSION
FILTRATION-RATE
BARIATRIC SURGERY
Journal
N
IF:
39.8
Papers:
2.2K
Citations:
1.9W