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GLU-GOD-FAM Composite Nanozyme: Synergistic Antibacterial Activity, Stable Catalysis, and Efficacy in Promoting Wound Healing for Clinical Care
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DOI：10.1002/cnma.70310.png)
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Abstract
En 中文
Traditional antibacterial systems are limited by poor stability of natural enzymes, weak antimicrobial activity of conventional nanozymes, and the need for exogenous H2O2 or pH adjustment, thus failing to meet the demands of clinical wound care. To address these issues, this study constructed a glucose oxidase-glucose-mineral-based composite nanozyme (GLU-GOD-FAM) antibacterial system and systematically evaluated its catalytic mechanism, stability, antimicrobial activity, in vivo wound healing efficacy, and biosafety. Results showed that FAM overcame the inactivation of natural enzymes under high temperature or UV irradiation; GLU-GOD-FAM exhibited a “1 + 1 > 2” synergistic antimicrobial effect, achieving 100% bactericidal rate against E. coli and S. aureus without exogenous H2O2 supplementation or pH adjustment. In vivo, it accelerated the healing of infected and noninfected mouse dorsal wounds and caused no obvious damage to major organs. This stable, efficient, and safe system provides a novel candidate for clinical emergency wound care and postoperative infection control.
Keywords:
antibacterial activity
GLU-GOD-FAM
wound healing
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