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Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery

delete2026-07-09
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OA
AI
Y
Yuto Hasegawa
H
Hiroki Kawai
R
Robyn Wiseman
G
Gianluca Ursini
H
Hannah Alton
F
Feiyi Xiong
S
Sohan Gummadi
N
Naomi Mao
K
Kyle Mailhot
Y
Yannan Li
X
Xiaolei Zhu
T
Tomoyo Sawada
B
Barbara Slusher
A
Atsushi Kamiya *
DOI:10.1002/alz.71666delete
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Abstract

Abstract

En 中文
Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood.
Keywords:
aging
astrocytes
glutamate carboxypeptidase II
glymphatic system
perioperative neurocognitive disorder
sex differences
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Journal

A
alzheimer's & dementia
IF:
0
Papers:
511
Citations:
0

Organization

J
johns hopkins university school of medicine
Scholars:
592
Papers: 180
Citations: 0
L
Lieber Institute for Brain Development
Scholars:
89
Papers: 22
Citations: 614