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Glycan targeting can recruit anti-tumor immunologic functions by lymphatic endothelium
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DOI：10.1016/j.neo.2026.101340.png)
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Abstract
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• Glycan under-sulfation boosts model antigen presentation by lymphatic endothelium. • CD8+ T cell activation is augmented by antigen-pulsed glycan targeted lymphatics. • This state drives increased lymph node CD8+ T cells with reduced metastases in vivo. • Glycan targeting of lymphatic endothelium may augment anti-cancer adaptive immunity.
Keywords:
T cells
Lymphatic
Immunity
Cytotoxic t-lymphocyte
Cancer
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