.png){kind=icon}
Return
Go with the capillary flow. Simple thread-based microfluidics
.png){kind=icon}
PRE
AI
DOI：10.1016/j.snb.2021.129670.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Studies on microfluidic thread-based analytical devices (?TADs) have been developed for a decade. Threads, made of natural cellulose or synthesized polymer fibres, are manufactured in the form which possesses a large number of capillary gaps for liquid transport, and show differences in structural morphologies and surface chemistry. Threads have been used to design simple thread-based microfluidics with different analytical functions. Due to their low-cost, portability, biocompatibility and ease of integration with other components, threads show a great application basis to fabricate point-of-care ?TADs. To date, there are a limited number of published studies on ?TADs in contrast to paper-based analytical devices. To facilitate further advances of ?TADs, this review summarizes the development of these devices from the aspects of engineering control of capillary flow on threads and biological applications. Particularly, as liquid flow on threads affects the transport and detection efficiencies, strategies of controlling liquid flow on threads are firstly reviewed. This includes thread surface modification, proper thread type selection, and microfluidic channel design. Then various detection methods including colorimetry, fluorescence, electrochemistry and surface-enhanced Raman spectroscopy applied on ?TADs are reviewed. The biological applications of ?TADs in blood separation and analysis, immunoassay, wearable sensing, as well as compatibility with smartphones for biosensing are also systematically summarized. Finally, the future perspectives of ?TADs regarding external collaboration to satisfy the ?REASSURED? criteria are proposed. This review is expected to expand understandings of ?TAD designs and applications, and to clarify the challenges and future development directions of ?TADs.
Keywords:
Thread-based microfluidics
Capillary flow
Point-of-care
Diagnostics
Biological applications
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7.7
Papers:
3.4W
Citations:
12.6W
Organization
Cited Papers
ShareSave
ShareSaveShareSaveA cost-effective assay, for antioxidant using simple cotton thread combining paper based device with mobile phone detection.png)
TALANTA
TALANTAIF6.1
PREAI
ShareSaveEffects of plasma treatments for improving extreme wettability behavior of cotton fabricsCELLULOSE
CELLULOSEIF4.8
PREAI
ShareSaveShareSave
View more