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Golgi Positioning
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DOI：10.1101/cshperspect.a005322.png)
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Abstract
En 中文
The Golgi apparatus in mammalian cells is positioned near the centrosome-based microtubule-organizing center (Fig. 1). Secretory cargo moves inward in membrane carriers for delivery to Golgi membranes in which it is processed and packaged for transport outward to the plasma membrane. Cytoplasmic dynein motor proteins (herein termed dynein) primarily mediate inward cargo carrier movement and Golgi positioning. These motors move along microtubules toward microtubule minus-ends embedded in centrosomes. Centripetal motility is controlled by a host of regulators whose precise functions remain to be determined. Significantly, a specific Golgi receptor for dynein has not been identified. This has impaired progress toward elucidation of membrane-motor-microtubule attachment in the periphery and, after inward movement, recycling of the motor for another round. Pericentrosomal positioning of the Golgi apparatus is dynamic. It is regulated during critical cellular processes such as mitosis, differentiation, cell polarization, and cell migration. Positioning is also important as it aligns the Golgi along an axis of cell polarity. In certain cell types, this promotes secretion directed to the proximal plasma membrane domain thereby maintaining specializations critical for diverse processes including wound healing, immunological synapse formation, and axon determination.
Keywords:
MICROTUBULE-ORGANIZING CENTER
DYNEIN INTERMEDIATE CHAIN
CASPASE-MEDIATED CLEAVAGE
FAST AXONAL-TRANSPORT
CYTOPLASMIC DYNEIN
ENDOPLASMIC-RETICULUM
MEMBRANE-TRAFFICKING
CELL-CYCLE
IN-VITRO
ORGANELLE TRANSPORT
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