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Gonadotropin-Inhibitory Hormone (GnIH) Induces Glycolipid Metabolic Dysfunction in Porcine Ovarian Granulosa Cells via Wnt and AMPK Signaling Pathways
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DOI：10.1016/j.mce.2026.112813.png)
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Abstract
En 中文
• GnIH inhibits AMPK and activates canonical Wnt signaling, disrupting granulosa cell energy homeostasis and function. • GnIH suppresses glycolysis and mitochondrial ATP synthesis while enhancing lipogenesis and β-oxidation, leading to metabolic imbalance in granulosa cells. • GnIH induces oxidative stress and insulin resistance, compromising glucose uptake and mitochondrial dynamics in granulosa cells.
Keywords:
GnIH
granulosa cells
Wnt signaling
AMPK signaling
glycolipid metabolism
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3.6
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8.0K
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1.6W
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