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Greater burden of Alzheimer's Co-pathology in women with Parkinson's disease dementia
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DOI：10.1177/1877718x261470295.png)
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Abstract
En 中文
<jats:sec>
<jats:title>Objective</jats:title>
<jats:p>To investigate sex differences in Alzheimer's disease (AD) related pathology among autopsy-confirmed Parkinson's disease (PD) cases.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>AD and PD frequently co-occur in older adults, yet the influence of sex on AD pathology in the context of PD remains unexplored.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>All subjects were enrolled in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) and Brain and Body Donation Program (BBDP) and had annual standardized research clinical assessments by neuropsychologists, subspecialty behavioral and movement disorders neurologists, as well as comprehensive neuropathological examinations after death.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>
Among 230 autopsy-confirmed PD cases, females exhibited greater amyloid plaque pathology burden than males, regardless of a co-occurring AD diagnosis. Specifically, females with PD had significantly higher mean cortical total plaque scores (mean 6.5/15 vs. 4.9/15,
<jats:italic toggle="yes">p</jats:italic>
= 0.045) and greater CERAD neuritic plaque density (mean 1.7/3 vs. 1.3/3,
<jats:italic toggle="yes">p</jats:italic>
= 0.035). Females were also more likely to have a higher cortical plaque burden (plaque total ≥ 5: 56.8% vs. 39.7%,
<jats:italic toggle="yes">p</jats:italic>
= 0.015). In multivariable logistic regression models, female subjects showed greater than twice the odds of having an amyloid plaque burden ≥5 compared to males (OR = 2.18; 95% CI = 1.17–4.06;
<jats:italic toggle="yes">p</jats:italic>
= 0.014), when controlling for ApoE ε4 status, Lewy body density score, and age at death.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Female sex is associated with increased amyloid plaque pathology in PD, independent of ApoE ε4 status. These findings highlight a sex-specific vulnerability to AD pathology in PD patients and support the need for sex-informed approaches to reseach in mixed neurodegenerative disease.</jats:p>
</jats:sec>
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