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Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study

delete2026-07-06
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OA
AI
M
Miranda G Chappel-Farley *
K
Kelsey R. Sewell
A
Audrey M. Collins
C
Cristina Molina-Hidalgo
S
Shivangi Jain
H
Haiqing Huang
P
Patricio Solis-Urra
L
Lauren E. Oberlin
G
George Grove
A
Arthur F. Kramer
E
Edward McAuley
J
Jeffrey M. Burns
C
Charles Hillman
E
Eric D. Vidoni
B
Bradley P. Sutton
A
Anna L. Marsland
M
M. Ilyas Kamboh
C
Chaeryon Kang
L
Lu Wan
K
Kirk I. Erickson
K
Kristine A. Wilckens
DOI:10.1002/alz.71627delete
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Abstract

Abstract

En 中文
Poor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline. We tested whether poor sleep promotes neurodegeneration and cognitive deficits via ChP dysfunction.
Keywords:
accelerometry
aging
choroid plexus
cognition
neurodegeneration
older adults
sleep
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alzheimer's & dementia
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511
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adventhealth research institute
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university of pittsburgh school of medicine
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university of pittsburgh school of public health
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University of Illinois at Urbana-Champaign
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university of pittsburgh
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