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Green and efficient utilization of ethyl acetate-derived ester enolates for aldol condensation in continuous flow: from ultralow temperature to room temperature
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DOI：10.1016/j.gce.2026.07.001.png)
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Abstract
En 中文
• LDA-mediated aldol condensation of EA was achieved at r.t. in continuous flow. • High yields of β-hydroxy esters were obtained within 1.5 s for many electrophiles. • Rapid mixing and precise control over residence time were crucial for high yields. • Yields can be improved by flexibly adjusting the electrophile reaction temperature. • Efficient downstream functionalization was achieved on crude β-hydroxy esters.
Keywords:
Microchannels
Aldol condensation
β-Hydroxy esters
β-Hydroxy acids
Flow chemistry
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