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Green synthesis of zinc oxide nanoparticles using Croton joufra leaf extract, characterization and antidiabetic activity
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DOI：10.1007/s40089-023-00401-8.png)
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Abstract
En 中文
In this current investigation, zinc oxide nanoparticles (ZnONPs) were synthesized from Croton joufra leaves extract containing zinc nitrate as a precursor. Reducing zinc nitrate to free zinc nanoparticles under the impact of phytoconstituents of Croton joufra aqueous leaves extracts has successfully synthesized Croton joufra zinc oxide nanoparticles (Cj-ZnO NPs). The ultraviolet-visible (UV-Vis) spectroscopy revealed the maximum surface plasmon resonance at 346 nm. The Fourier transform infrared (FT-IR) spectroscopy showed a broad peak at 3269.53 cm(-1), 1605.67 cm(-1), 1070.14 cm(-1), and 1042.35 cm(-1) disclosing that the nanoparticle contained O-H carboxylic acid stretching, C = N bond, and C-O stretching vibrations. The highly stable Cj-ZnO NPs are repelled by one another, as exhibited by the negative charge of the zeta potential value (- 22.9 mV). The morphological characteristics of the synthesized nanoparticle were analyzed with X-ray diffraction (XRD), field emission scanning electron microscopy-energy dispersive X-ray (FESEM-EDX), scanning electron microscopy (SEM), transmittance electron microscopy (TEM), and differential scanning calorimetry (DSC) techniques. The synthesized Cj-ZnO NPs showed in vitro antidiabetic activity with an IC50 value of 774.86 mu g/ml, while metformin was used as a standard drug with an IC50 value of 538.24 mu g/ml. This study demonstrates the possibility of using Cj-ZnONPs to treat diabetes.
Keywords:
Zinc oxide nanoparticles
Croton joufra
Nanonization
Antidiabetic activity
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