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Growth differentiation factor 15 impairs periodontal ligament stem cell proteostasis via integrated stress response to drive diabetic periodontitis

delete2026-08-07
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OA
AI
X
Xiaoyu Yang
H
Han Li
H
He Wang
H
Houxuan Li
S
Shuhong Li
Y
Yiyao Hu
D
Deping Zeng
J
Junji Xu *
J
Jinlin Song *
J
Jie Li *
DOI：10.1016/j.jare.2026.08.007delete
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Abstract

Abstract

En 中文
• PDLSCs exhibit enhanced activation of the ISR in periodontitis with T2DM. • GDF15 contributes to persistent ISR-associated proteostatic dysfunction. • GDF15 loss restores PDLSC protein synthesis and osteogenic capacity. • Local GDF15 neutralization improves periodontal regeneration in diabetic mice.
Keywords:
Growth differentiation factor 15
Integrated stress response
Periodontal ligament stem cells
Type 2 diabetes mellitus
Periodontitis

Journal

Journal of Advanced Research cover
Journal of Advanced Research
IF:
13
Papers:
2.8K
Citations:
1.4W

Organization

C
Chongqing Medical University
Scholars:
5.9K
Papers: 1.5K
Citations: 2.8W
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