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Growth Model for Continuous Culture of a Hydrogen-Oxidizing Bacterium, Hydrogenophilus thermoluteolus Strain TH-1
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DOI：10.1002/bit.70292.png)
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Abstract
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Hydrogenophilus thermoluteolus strain TH-1 is a thermophilic hydrogen-oxidizing bacterium that can autotrophically grow using H2, CO2, and O2 with the highest rate among autotrophs. However, despite its significant potential for use in biomanufacturing from CO2, no model to date has accurately described strain TH-1 growth under both H2- and O2-limiting conditions. Here, we report on a growth model for continuous culture. Theoretical equations were established for cell yields from the substrate consumption, overall mass transfer coefficients of H2 and O2, cell densities, and dilution rates. These equations were globally fitted to a series of cell culture profiles. Global fitting showed that the model closely reproduced cell production in continuous culture under H2-limiting and O2-limiting conditions. This model will be useful for understanding culture profiles and optimizing production.
Keywords:
carbon dioxide
cell productivity
global fitting
hydrogen-oxidizing bacteria
overall mass transfer coefficient
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