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Gut microbiota at the crossroads of cocaine use and binge eating disorders
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DOI：10.3389/fnbeh.2026.1841613.png)
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Abstract
En 中文
Binge eating disorder (BED) and cocaine use disorder (CUD) are two major public health concerns characterized by impaired control over consumption and significant impacts on physical and mental health. BED; the most prevalent eating disorder; involves recurrent episodes of excessive intake of highly palatable foods; while CUD is marked by compulsive cocaine use. Both disorders involve neurotransmitters dysregulation prompting research into their neurobiological overlap. Emerging clinical and preclinical research highlights the microbiome as a critical modulator of behavior and mental health. This review critically evaluates the role of the microbiome in BED and CUD; focusing on preclinical and clinical evidence on microbial composition and functional pathways; including microbiome-targeted interventions. We highlight gaps in the current literature that warrant further investigation. Microbial alterations may serve as one potential biomarker to clarify shared or distinct mechanisms in the progression and maintenance of the pathophysiology of these disorders.
Keywords:
microbiota
gut-brain axis
addiction
binge eating disorder
cocaine use disorder
Journal
IF:
2.9
Papers:
385
Citations:
1.1W
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Cited Papers