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GW-9662, a peroxisome proliferator-activated receptor γ (PPARγ) inhibitor, impairs early embryonic development in zebrafish
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DOI：10.1016/j.cbpc.2025.110332.png)
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Abstract
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• GW-9662 exposures induce ventralization in zebrafish embryos • Western Blot and immunohistochemistry shows that GW-9662-induced PPARγ inhibition may be localized. • GW-9662 induces strong transcriptomic disruptions • Cytoskeletal proteins and epithelial-to-mesenchymal markers are disrupted • Intracellular lipids are elevated
Keywords:
PPARγ
GW9662
Zebrafish
Embryogenesis
Lipid
Cytoskeletal
Epithelial-to-mesenchymal transition
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