.png){kind=icon}
.png){kind=icon}
Return
Gynecological complications following allogeneic hematopoietic cell transplantation and clinical management recommendations: a scoping review protocol
.png){kind=icon}
OA
AI
C
C
J
L
D
M
C
DOI：10.1186/s13643-026-03283-x.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Allogeneic hematopoietic cell transplantation (HCT) has become a curative treatment option for many hematological disorders. However, female recipients face unique challenges related to their reproductive and gynecological health that are often overlooked in clinical practice and research. Despite the growing recognition of sex and gender considerations in transplantation medicine, there remains a significant gap in data to devise comprehensive guidelines addressing gynecological health concerns specifically following allogeneic HCT. These complications can significantly impact quality of life, fertility, sexual function, and long-term health outcomes. We will conduct a scoping review to map and synthesize the available evidence on gynecological health concerns following allogeneic HCT and their clinical management. Our review will include female recipients of allogeneic HCT ≥ 18 years old. We will search MEDLINE, Embase, CINAHL, and the APA PsycINFO for relevant literature without date or language restrictions. Additionally, we will search gray literature sources including clinical trial registries and transplantation and gynecological society guidelines. Two reviewers will independently evaluate the eligibility of all identified titles and abstracts for inclusion in the full text review, as well as data extraction. Data extraction will focus on types of gynecological complications, their prevalence or incidence, and identified risk factors, screening and treatment approaches, clinical outcomes, and management recommendations. Descriptive statistics and narrative synthesis will be used to analyze and present the findings. This scoping review will consolidate the current knowledge on gynecological health concerns following allogeneic HCT and identify best practices for their management. Our findings will highlight critical gaps in current medical literature and practice, paving the way to inform the development of evidence-based clinical management recommendations for female allogeneic HCT recipients. By addressing this understudied aspect of transplantation medicine, our review aims to improve overall health, enhance quality of life, and ensure comprehensive personalized care for women undergoing HCT. https://doi.org/10.17605/OSF.IO/5NPJF
Keywords:
Allogeneic hematopoietic cell transplantation
Women
Gynecology
Journal
IF:
3.9
Papers:
2.8K
Citations:
1.8W
Organization
Cited Papers