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H₂O₂-induced oxidative stress modulates methotrexate and dexamethasone-dependent regulation of NLRP3-associated transcription and HLA class I expression in primary human RPE cells
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DOI：10.1016/j.ejps.2026.107575.png)
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Abstract
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• MTX and DEX modulate NLRP3-related gene expression and HLA class I expression in primary human retinal pigment epithelial cells under basal and H₂O₂-induced oxidative stress conditions. • Changes in transcriptional profiles of NLRP3- and antigen-presentation–related genes under H₂O₂-induced conditions are not paralleled by proportional alterations in IL-1β secretion. • Combination therapy is associated with reduced IL-18 secretion under oxidative stress conditions.
Keywords:
Retinal pigment epithelium
NLRP3 inflammasome
HLA class I
Oxidative stress
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