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Harnessing exosomes for advanced drug delivery in cancer theranostics
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DOI：10.1016/j.ijpharm.2026.126966.png)
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Abstract
En 中文
Exosomes are nanoscale extracellular vesicles released by various cell types and have gained significant attention for their ability to transport diverse bioactive molecules. Their inherent stability, tumor-targeting capability, biocompatibility, and low immunogenicity make them promising candidates for drug delivery in cancer therapy. Despite these advantages, a gap remains between their biological understanding and optimal clinical application. Exosomes play a dual role in cancer as both therapeutic delivery systems and mediators of disease progression. Their phospholipid membrane enhances targeted drug delivery, while exosome-associated biomarkers offer new opportunities for cancer diagnosis. This review provides a comprehensive overview of exosome biogenesis, isolation methods, cargo loading strategies, roles in cancer progression, and applications in drug delivery and theranostics. It also highlights the advantages, limitations, and current clinical advancements of exosome-based systems. Overall, exosomes represent a cutting-edge platform with the potential to transform future cancer diagnosis and treatment.
Keywords:
Exosomes
Drug delivery
Cancer theranostics
Biogenesis
Cargo loading
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5.2
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6.7W
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