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Harnessing the Power of IL-12: Revolutionizing Cancer Therapy with Combinatorial Strategies

delete2026-06-23
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PRE
AI
Y
Yuxi Zhang
J
Jing Tian
X
Xiangdong Gao *
J
Jun Yin *
DOI：10.1016/j.cyto.2026.157180delete
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Abstract

Abstract

En 中文
• IL-12 reshapes the TME and boosts cytotoxic lymphocyte-mediated antitumor immunity. • Combining IL-12 with ICIs reverses T cell exhaustion and strengthens checkpoint blockade. • IL-12 enhances chemotherapy-induced immunogenicity and restores immune responsiveness. • IL-12-armored CAR-T cells improve intratumoral activation and show promise in solid tumors. • Advanced delivery platforms enable tumor-restricted IL-12 expression to reduce toxicity.

Journal

Cytokine cover
Cytokine
IF:
3.7
Papers:
9.7K
Citations:
1.4W

Organization

C
china pharmaceutical university
Scholars:
3.0K
Papers: 627
Citations: 0
C
china medical university
Scholars:
3.9K
Papers: 1.3K
Citations: 0
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