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Heartbeats and hidden codes: Decoding cardiac aging with multi-omics and computational approaches
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DOI：10.1016/j.yjmcc.2026.05.005.png)
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Abstract
En 中文
• Cardiac aging reflects pronounced cell-type-specific remodeling across the myocardium • Single-cell dual-omics identifies fibroblasts and macrophages as key aging-responsive cells • Aging in these cells is associated with senescence, altered communication, and chromatin changes • Integrating bulk and single-cell omics refines mechanistic hypotheses in cardiac aging • Computational approaches support scalable analysis of complex single-cell aging datasets
Keywords:
Cardiac aging
Single-cell dual-omics
Fibroblasts
Macrophages
Computational analysis
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