.png){kind=icon}
.png){kind=icon}
Return
Hematological trajectories and pregnancy complications in essential thrombocythemia and polycythemia vera
.png){kind=icon}
OA
AI
F
F
C
M
M
V
L
C
H
H
DOI：10.1007/s00277-026-07236-1.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Women with essential thrombocythemia (ET) and polycythemia vera (PV) are at increased risk of pregnancy complications. During pregnancy, hematologic parameters tend to approach normal values, and previous studies have reported that a greater decline in platelet counts in ET is associated with reduced risk of complications. In this study, we examined longitudinal trajectories of platelet count, hemoglobin, hematocrit, and leukocyte count during pregnancy, characterized pregnancy outcomes, and investigated the association between platelet trajectories and preeclampsia. We established a longitudinal cohort of pregnant women with ET and PV in the Capital Region and Region Zealand between 2010 and 2024, using data from regional laboratory information systems and Danish health registries. In total, 41 ET and 5 PV pregnancies in 35 women were included. The mean age at MPN diagnosis was 30.1 years in women with ET and 34.1 years in women with PV. In ET pregnancies, platelet counts, hemoglobin, hematocrit and leukocyte count changed by − 44%, − 5%, − 12% and + 55%, respectively, from baseline to delivery, and in PV pregnancies − 36%, − 26%, − 25% and + 47%, respectively. Overall, 29% of ET pregnancies had a maternal complication, with preeclampsia being the most common (12%). ET women who developed preeclampsia had significantly higher platelet counts before pregnancy and experienced a greater decline in platelet counts during pregnancy than women without preeclampsia. Thus, hematologic trajectories during pregnancy may help identify women at increased risk of preeclampsia.
Keywords:
Essential thrombocythemia
Polycythemia vera
Myeloproliferative neoplasms
Pregnancy
Preeclampsia
Platelet counts
Journal
IF:
2.4
Papers:
8.3K
Citations:
8.1K
Organization
Cited Papers