Hemerocallis lilioasphodelus root water extract ameliorates non-alcoholic fatty liver disease by regulating the gut-liver axis and activating AMPK-mediated lipid metabolism: an integrated study based on metabolomics and 16S rRNA sequencing

2026-08-10

PRE

Liqiu Zhang

Shengxi Lin

Jiayu Li

Zimo Wang

Huiling Cui

Feifei Bao

Yuning Di

Chengbin Xu

Tianbin Dai

Haidan Yuan *

Guangchun Piao *

DOI：10.1016/j.jep.2026.122287

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• UHPLC-QE-MS reveals chemical profile and serum-absorbed constituents of HL. • HL reverses hepatic steatosis in a 12-week HFD-induced NAFLD mouse model. • HL regulates the gut-liver axis to reshape microbiota. • HL restores intestinal barrier via ZO-1, Occludin, Claudin-1, reducing gut-derived stressors. • HL suppresses lipogenic cascades by activating the AMPK/SREBP1c pathway.

Hemerocallis lilioasphodelus root water extract ameliorates non-alcoholic fatty liver disease by regulating the gut-liver axis and activating AMPK-mediated lipid metabolism: an integrated study based on metabolomics and 16S rRNA sequencing

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