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Heparan sulfate buffers the bone resorptive activity of cathepsin K in bone homeostasis
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DOI：10.1016/j.matbio.2026.102009.png)
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Abstract
En 中文
• Cathepsin K–heparan sulfate interaction is required for normal bone homeostasis. • Heparan sulfate-binding deficient CtsK is hyperactive under C57BL/6 background, leading to an osteoporotic phenotype. • Heparan sulfate-binding deficient CtsK is hypoactive under 129S1 background, resulting in increased bone mass. • Heparan sulfate likely functions as a buffer to prevent excessive and promote sustained bone resorption.
Keywords:
Cathepsin K
heparan sulfate
bone homeostasis
bone resorption
osteoporosis
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4.8
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