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Hepatocyte Transforming Growth Factor-β–Oxyterol-Binding Protein Related 3 Signaling Axis Promotes Hepatic Stellate Cell Activation and Liver Fibrogenesis in Mice
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DOI：10.1016/j.jcmgh.2026.101845.png)
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Abstract
En 中文
Prolonged activation of hepatocyte transforming growth factor β signaling has been identified as a key driver of hepatic stellate cell activation, leading to liver fibrosis in chronic liver diseases. However, the mechanisms by which overactivation of transforming growth factor β signaling within hepatocytes promotes hepatic stellate cell activation and liver fibrosis remain poorly understood. The expression of oxyterol-binding protein related 3 is markedly induced in human fatty liver samples. However, the regulation and function of hepatic oxyterol-binding protein related 3 in the pathogenesis of liver fibrosis are currently unknown.
Keywords:
Activation of HSCs
Liver Fibrosis
ORP3
Profibrogenic Factors
TGF-β Signaling
α-SMA
α-smooth muscle actin
CCl4
carbon tetrachloride
COL1A1
collagen type I alpha 1 chain
CTGF
connective tissue growth factor
E2F1
E2F transcription factor 1
HFLMCD
high-fat, low-methionine, choline-deficient
HSC
hepatic stellate cell
IF
immunofluorescence
IHC
immunohistochemistry
JNK
c-Jun N-terminal kinase
MASH
metabolic dysfunction–associated steatohepatitis
MASLD
metabolic dysfunction–associated steatotic liver disease
mRNA
messenger RNA
ORP3
oxyterol-binding protein related 3
PBS
phosphate-buffered saline
PMH
primary mouse hepatocyte
qPCR
quantitative polymerase chain reaction
shRNA
short hairpin RNA
snRNA-seq
small nuclear RNA sequencing
TGFβ
transforming growth factor β
THBS1
thrombospondin-1
WT
wild-type
YAP
Yes-associated protein
Journal
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7.4
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1.5K
Citations:
6.8K
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