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Hierarchical models for multicentre binary response studies
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DOI：10.1002/sim.4780090808.png)
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Abstract
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AbstractA three‐stage hierarchical model is proposed for two treatment, binary response studies conducted in a number of centres. The approach adopted is Bayesian. Marginal densities for second stage parameters are shown to provide useful summaries both of comparative efficacy and of the heterogeneity of treatment effects across centres. Sensitivity studies of model assumptions are illustrated.
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