Patient, Care Partner, and Oncologist Perspectives on Clinically Important Survival Thresholds After Considering Time Toxicity in Advanced Cancer

Arjun Gupta, MD

doi:10.1093/oncolo/oyag246

High dietary fat causes muscle structural breakdown, mitochondrial dysfunction, and contractile deficits in the absence of carnitine palmitoyltransferase 2

2026-06-22

0

PRE

AI

A

Andrea S. Pereyra

F

Filip Jevtovic

A

Adam J. Amorese

C

Chien-Te Lin

P

P. Darrell Neufer

E

Espen E. Spangenburg

J

Jessica M. Ellis *

DOI：10.1016/j.ymgme.2026.110197

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• High fat diet impairs muscle performance and force production in CPT2 deficient mice. • High fat diet induces ragged red fibers and structural damage in CPT2-deficient muscle. • High fat diet exacerbates myopathy features in CPT2 deficiency by increased lipid and mitochondria accumulation in myofibers.

High dietary fat causes muscle structural breakdown, mitochondrial dysfunction, and contractile deficits in the absence of carnitine palmitoyltransferase 2

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