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High-intensity interval training attenuates post-myocardial infarction remodeling and ITGAM-mediated M4 macrophage polarization
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DOI：10.1016/j.lfs.2026.124598.png)
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Abstract
En 中文
• Intense interval training confers robust cardioprotection post-infarction. • The training specifically attenuates pathogenic M4 macrophage polarization. • This cardioprotection is mediated by targeted downregulation of ITGAM. • Targeting ITGAM rescues cardiomyocytes from macrophage-induced apoptosis.
Keywords:
ANOVA
,
Analysis of Variance
CAD
,
Coronary Artery Disease
CCK-8
,
Cell Counting Kit-8
CXCL4
,
C-X-C Motif Chemokine Ligand 4
DEG
,
Differentially Expressed Gene
ELISA
,
Enzyme-Linked Immunosorbent Assay
GO
,
Gene Ontology
H&E
,
Hematoxylin and Eosin
HIIT
,
High-Intensity Interval Training
IL-6
,
Interleukin 6
ITGAM
,
Integrin Subunit Alpha M
LAD
,
Left Anterior Descending Artery
LVEF
,
Left Ventricular Ejection Fraction
LVFS
,
Left Ventricular Fractional Shortening
M-CSF
,
Macrophage Colony-Stimulating Factor
MI
,
Myocardial Infarction
MICT
,
Moderate-Intensity Continuous Training
MMP7
,
Matrix Metalloproteinase 7
PBMC
,
Peripheral Blood Mononuclear Cell
PF4
,
Platelet Factor 4
PPI
,
Protein-Protein Interaction
RT-qPCR
,
Quantitative Reverse Transcription Polymerase Chain Reaction
SD
,
Standard Deviation
Sed
,
Sedentary
siRNA
,
Small Interfering RNA
TNF-α
,
Tumor Necrosis Factor Alpha
WGA
,
Wheat Germ Agglutinin
Cardiac Rehabilitation
High-Intensity Interval Training
Macrophage
Myocardial Infarction
Journal
IF:
5.1
Papers:
1.7W
Citations:
4.7W
Organization
Cited Papers