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High-throughput solid microsampling through stochastic robotic automation
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DOI：10.1038/s42004-026-02153-w.png)
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Abstract
En 中文
Solid sampling at the sub-milligram and milligram scale remains a major bottleneck for high-throughput chemistry or material sciences, as existing approaches rely on manual handling or slow deterministic microsampling that do not readily scale. Here we present STORMS, an automated STOchastic Robotic MicroSampling system that enables fast, reliable and parallel sampling of solid materials at sub-milligram and milligram masses. Rather than attempting deterministic mass control, STORMS leverages stochastic sampling combined with robotic automation, and glass encapsulation to achieve statistically robust and reproducible sample collection. We show that this approach delivers high precision and throughput across a range of solid materials, while supporting straightforward parallelization thanks to encapsulation and minimal operator intervention. Benchmarking against conventional sampling workflows demonstrates substantial gains in speed and reproducibility. By decoupling sampling reliability from deterministic mass control, STORMS establishes stochastic microsampling as a general and scalable strategy for solid analysis at the sub-milligram and milligram scale. High-throughput chemistry faces challenges in scaling solid sampling at sub-milligram and milligram levels due to manual and slow methods. Here, the authors introduce STORMS, an automated stochastic robotic microsampling system that enhances speed, precision, and reproducibility, offering a scalable solution for solid analysis with minimal operator intervention.
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