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Highly efficient construction of angular polycycles
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DOI：10.1038/s41467-024-53562-1.png)
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Abstract
En 中文
Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. We herein report the Lewis acids-catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring, by which structurally complex and diverse angular tricyclic and polycyclic carbocycles were efficiently constructed from cheap and easily available feedstock and with convenient operation. This is also the example of (3 + 2) cycloaddition of a C3-synthon with the C = C of benzene. We believe this will demonstrate its potential in the total syntheses of natural products and drug discovery. Angular tricyclic and polycyclic skeletons feature typical cores in an intriguing type of natural products. Herein, the authors report Lewis acids catalyzed dearomative (3 + 2) cycloadditions of donor-acceptor cyclopropanes with benzene ring for the synthesis of diverse angular tricyclic and polycyclic carbocycles.
Keywords:
CYCLOPROPANE 1,1-DIESTERS
META-PHOTOCYCLOADDITION
NATURAL-PRODUCTS
CYCLOADDITIONS
DERIVATIVES
DITERPENES
STRATEGIES
LAURENENE
PARALLEL
SKELETON
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