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Highly Expandable Portable Gravity-Driven Multiplexable Raman Sensor
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DOI：10.1109/JPHOT.2025.3633421.png)
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Abstract
En 中文
Microfluidics is expected to replace traditional medical detection methods as the next generation medical detection technology due to its high throughput, less sample required, and fast mass transfer. However, microfluidic chips mostly need a peristaltic pump to provide pressure to feed the sample, which limits its capability of immediate detection as well as portability. In this paper, a gravity-driven droplet-based microfluidic multiplexed Raman sensor has been developed, which is applicable to both rigid and flexible substrates. Furthermore, the fabrication method is also proposed. The developed gravity-driven multiplexed Raman sensor is easy to manufacture, thin, cheap and does not require external energy input. The performance of the developed sensor was characterized by using malachite green, and the minimum 10(-8) mol/L malachite green can be detected with 633 nm laser irradiation. Moreover, we optimized its dimensions, while retaining its excellent features such as easy fabrication, cost-effectiveness and thinness. The proposed sensor provides a new view for portable on-chip detection of liquid droplets.
Keywords:
Substrates
Silicon
Microfluidics
Multiplexing
Etching
Resists
Liquids
Coatings
Surface topography
Nitrogen
Miniaturized fluidic systems
simultaneous analysis of multiple samples
Raman spectroscopy-based detection
miniature and nanoscale fabrication
portable sensors
Journal
I
IF:
2.4
Papers:
194
Citations:
1.1W
Organization
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