.png){kind=icon}
.png){kind=icon}
Return
Highly sensitive electrochemical determination of chloramphenicol based on self-assembled electrode with polyoxometalate and molecularly imprinted polymer
.png){kind=icon}
PRE
AI
Y
W
C
M
J
DOI：10.1007/s10800-026-02467-6.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
A novel highly sensitive modified electrode containing water-insoluble molecularly imprinted polymer (MIP) and Dawson-type phosphotungstic acid (H6P2W18O62, P2W18) was successfully fabricated using the electrostatic layer-by-layer (LbL) self-assembly method. The MIP was synthesized with N-isopropylacrylamide as the functional monomer and ethylene glycol dimethacrylate as the crosslinker. The modified electrodes were comprehensively characterized using Ultraviolet-Visible spectroscopy (UV-Vis), Infrared spectroscopy (IR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Their electrochemical sensing performance for chloramphenicol was evaluated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). The MIP-P2W18 composite-modified electrode exhibited superior sensitivity and selectivity over P2W18-only modified electrodes, attributable to signal-enhanced molecular discrimination of MIPs via specific recognition cavities. Electrochemical results (DPV) showed a wide detection range (1 nM - 10 & micro;M), low detection limit (0.1 nM), superior anti-interference ability, reliable stability, good reproducibility and moderate repeatability. Furthermore, the electrode was applied for the rapid detection of chloramphenicol in milk samples, and F-test and t-test were conducted to ensure the precision and reliability of the real-sample detection. To our knowledge, the integration of water-insoluble MIPs into electrochemical sensors through facile and efficient LbL self-assembly to enhance the selectivity and lower the detection limit of chloramphenicol has rarely been reported.
Keywords:
Molecularly imprinted polymers
Polyoxometalates
Layer-by-layer self-assembly
Highly sensitive detection
Chloramphenicol
Journal
IF:
3
Papers:
963
Citations:
9.0K
Organization
Cited Papers