.png){kind=icon}
.png){kind=icon}
Return
Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain
.png){kind=icon}
OA
AI
DOI：10.1038/s41467-024-49823-8.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks. Here the authors introduced a multimodal comparative framework to study the primate hippocampus. Despite expected structural conservation, they also observed functional reconfiguration, reflecting evolutionary changes to brain network integration.
Keywords:
DEFAULT MODE
SEGMENTATION
ORGANIZATION
CORTEX
MEMORY
NETWORK
MRI
NEOCORTEX
ANATOMY
MONKEY
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
15.7
Papers:
9.2W
Citations:
91.2W