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Hispidulin Ameliorates Androgenetic Alopecia by Inhibiting Dermal Papilla Cell Ferroptosis via TRPML1 Channel Activation

delete2026-07-27
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PRE
AI
X
Xiaofan Jin
H
Hongyan Zhang
Y
Yetan Shi
D
Dongfan Wei
W
Wen Xu
S
Shiqi Fu
H
Huasen Chen
X
Xiuzu Song *
DOI：10.1016/j.freeradbiomed.2026.07.040delete
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Abstract

Abstract

En 中文
• Hispidulin promotes hair regrowth in an androgenetic alopecia mouse model. • Structure-based docking identifies Hispidulin as a novel TRPML1 agonist. • Hispidulin inhibits DHT-induced ferroptosis in dermal papilla cells. • TRPML1 activation restores cellular iron homeostasis to prevent hair loss. • Targeting the TRPML1-ferroptosis axis offers a new therapeutic strategy.

Journal

Free Radical Biology and Medicine cover
Free Radical Biology and Medicine
IF:
8.2
Papers:
2.1W
Citations:
5.4W

Organization

H
Hangzhou Third People's Hospital
Scholars:
30
Papers: 14
Citations: 0
C
capital medical university
Scholars:
1.2W
Papers: 3.2K
Citations: 0
H
hangzhou dermatology hospital
Scholars:
5
Papers: 1
Citations: 0
Z
zhejiang university
Scholars:
17.0W
Papers: 11.9W
Citations: 152
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