Histone Deacetylases Inhibitor Chidamide Mitigates Inflammation and Insulin Resistance by Targeting VDR in Skeletal Muscle Cells

2026-04-04

PRE

Lulu Zhang

Maosen Zhang

Meng Zhu

Xinyu Luo

Longfei Cui

Yunfei Zhao *

Zhao, JM *

DOI：10.1016/j.mce.2026.112801

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Abstract

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• Chidamide mitigates PA-induced inflammation and insulin resistance in C2C12 cells. • VDR regulates Akt/GSK3β/AS160-mediated GLUT4 translocation and insulin signaling. • VDR upregulation is essential for the protective effects of Chidamide.

Keywords:

Chidamide

VDR

insulin resistance

inflammation

GLUT4 translocation

Histone Deacetylases Inhibitor Chidamide Mitigates Inflammation and Insulin Resistance by Targeting VDR in Skeletal Muscle Cells

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