HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study

Cynthia Lungu

doi:10.1016/j.ebiom.2026.106411

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study

2026-08-01

0

OA

AI

C

Cynthia Lungu *

T

Tanvir Hossain

R

Raquel Crespo

H

Henrieke Prins

K

Kathryn S. Hensley

C

Casper Rokx

S

Shringar Rao

J

Jeroen J. A. van Kampen

D

David A.M.C. van de Vijver

T

Thibault Mésplède

P

Peter D. Katsikis

R

Rob A. Gruters

Y

Yvonne M. Mueller

T

Tokameh Mahmoudi *

DOI：10.1016/j.ebiom.2026.106411

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Abstract

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Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment. While short-term dynamics of HIV-1 rebound following treatment interruption have been extensively studied, the longer-term consequences of immune perturbation and transient viraemia for reservoir quality and immune architecture remain incompletely understood.

Keywords:

Inducible HIV-1 reservoir

Tat/rev multiply spliced RNA

Immune phenotypes

CXCR3

Central memory CD4+ T cells

Trial endpoints

Analytical treatment interruption

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study

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