.png){kind=icon}
.png){kind=icon}
Return
HIV: Cell Binding and Entry
.png){kind=icon}
OA
AI
DOI：10.1101/cshperspect.a006866.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system. HIV uses a complex series of steps to deliver its genome into the host cell cytoplasm while simultaneously evading the host immune response. To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequential binding triggers fusion of the viral and host cell membranes, initiating infection. Revealing the mechanism of HIV entry has profound implications for viral tropism, transmission, pathogenesis, and therapeutic intervention. Here, we provide an overview into the mechanism of HIV entry, provide historical context to key discoveries, discuss recent advances, and speculate on future directions in the field.
Keywords:
IMMUNODEFICIENCY-VIRUS TYPE-1
GP120 ENVELOPE GLYCOPROTEIN
CHEMOKINE RECEPTOR GENE
TYROSINE KINASE P56LCK
D-PEPTIDE INHIBITORS
DENDRITIC CELLS
T-CELLS
VIROLOGICAL SYNAPSE
INTEGRIN ALPHA(4)BETA(7)
DISEASE PROGRESSION
Journal
IF:
10.1
Papers:
3.0K
Citations:
1.3W