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HNF4α promotes urate excretion by activating ABCG2 and mediates the anti-hyperuricemic effect of saffron floral bio-residue
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DOI：10.1016/j.phymed.2026.158680.png)
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Abstract
En 中文
Current pharmacotherapies for hyperuricemia (HUA) are limited by variable efficacy and adverse effects, highlighting the urgent need for novel therapeutic targets and agents. The natural product saffron floral bio-residue (SFB) has demonstrated anti-hyperuricemic potential, but the underlying molecular mechanism remains unclear.
Keywords:
Hyperuricemia
HNF4α
ABCG2
Saffron floral bio-residue
Kaempferol-3-O-sophoroside
ABCG2
,
ATP-binding cassette subfamily G member 2
BUN
,
Blood urea nitrogen
CRE
,
Creatinine
GSH-Px
,
Glutathione peroxidase
GWAS
,
Genome-wide association studies
HNF4α
,
Hepatocyte nuclear factor 4 alpha
HUA
,
Hyperuricemia
IL-1β
,
Interleukin-1β
KS
,
Kaempferol-3-O-sophoroside
MDA
,
Malondialdehyde
PO
,
Potassium oxonate
R
,
Rifampicin
SFB
,
Saffron floral bio-residue
SOD
,
Superoxide dismutase
TNF-α
,
Tumor necrosis factor-α
UA
,
Uric acid
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